Current advancements in self-assembling nanocarriers-based siRNA delivery for cancer therapy

G Kandasamy, D Maity - Colloids and Surfaces B: Biointerfaces, 2023 - Elsevier
Different therapeutic practices for treating cancers have significantly evolved to compensate
and/or overcome the failures in conventional methodologies. The demonstrated potentiality …

siRNA-based novel therapeutic strategies to improve effectiveness of antivirals: an insight

K Chatterjee, S Lakdawala, SS Quadir, D Puri… - AAPS …, 2023 - Springer
Since the ground-breaking discovery of RNA interference (RNAi), scientists have made
significant progress in the field of small interfering RNA (siRNA) treatments. Due to severe …

Exploiting the immune system in hepatic tumor targeting: unleashing the potential of drugs, natural products, and nanoparticles

CY Hsu, MA Mustafa, A Kumar, A Pramanik… - … -Research and Practice, 2024 - Elsevier
Hepatic tumors present a formidable challenge in cancer therapeutics, necessitating the
exploration of novel treatment strategies. In recent years, targeting the immune system has …

Investigation of a dual siRNA/chemotherapy delivery system for breast cancer therapy

Y Zhao, T Liu, A Ardana, NL Fletcher, ZH Houston… - ACS …, 2022 - ACS Publications
Multidrug resistance (MDR) is a problem that is often associated with a poor clinical outcome
in chemotherapeutic cancer treatment. MDR may potentially be overcome by utilizing …

Virus-like particles for TEM regulation and antitumor therapy

Z Yang, Y Chi, J Bao, X Zhao, J Zhang… - Journal of Functional …, 2022 - mdpi.com
Tumor development and metastasis are intimately associated with the tumor
microenvironment (TME), and it is difficult for vector-restricted drugs to act on the TME for …

Altered Expressions of PTEN, p53, Bax and Bcl-2 Genes by a Bioactive Pigment from Streptomyces sp. JUA14 Mediate Apoptosis of Cancer Cells

B Gajaraj, VK Nadumane - Applied Biochemistry and Microbiology, 2023 - Springer
Cancer is one of the leading causes of death around the world with major side effects for
existing therapies. The current study was aimed to extract pigments from microbial isolates …

Nanoliposomes as nonviral vectors in cancer gene therapy

SN Yildiz, M Entezari, MDA Paskeh, S Mirzaei… - MedComm, 2024 - Wiley Online Library
Nonviral vectors, such as liposomes, offer potential for targeted gene delivery in cancer
therapy. Liposomes, composed of phospholipid vesicles, have demonstrated efficacy as …

Alleviation of doxorubicin-induced cardiomyocyte death through miR-147-y-mediated mitophagy

H Gao, G Xian, G Zhong, B Huang, S Liang… - Biochemical and …, 2022 - Elsevier
Doxorubicin (DOX) is a commonly used antitumor drug. However, it may cause severe
cardiotoxicity, apoptosis being a major change. A recent report indicates that miR-147 …

Synthesis and characterization of magnetic polymeric nanocomposites for pH-sensitive controlled release of methotrexate

J Wu, X Wang, B Zhu, Q He, Y Zhang… - Journal of Biomaterials …, 2022 - Taylor & Francis
As one of the well-known anticancer drugs, methotrexate (MTX) has been limited in clinical
application due to its side effects on normal tissues. This study focused on the one-step …

Targeted siRNA nanotherapeutics against breast and ovarian metastatic cancer: a comprehensive review of the literature

A Subhan, SA Attia, VP Torchilin - Nanomedicine, 2022 - Taylor & Francis
Metastasis is considered the major cause of unsuccessful cancer therapy. The metastatic
development requires tumor cells to leave their initial site, circulate in the blood stream …