Nicorandil exerts myocardial protection through its antihypoxia and antioxidant effects. Here,
we investigated whether it plays an anti‐apoptotic role in diabetic cardiomyopathy. Sprague …

Nicorandil (NIC) is a well-known anti-anginal agent, which has been recommended as one
of the second-line treatments for chronic stable angina as justified by the European …

Blood–brain barrier (BBB) disruption, inflammation, and cell death are the pathogenic
mechanisms of cerebral ischemia/reperfusion (I/R) injury. Nicorandil protects ischemic injury …

Purpose Doxorubicin-induced cardiotoxicity (DIC) is a common side effect of doxorubicin
chemotherapy, and a major mechanism of DIC is inflammation. However, no effective …

Methotrexate (MTX) is a widely used chemotherapeutic agent but its clinical use is
challenged with different forms of toxicities including testicular injury. The aim of the current …

Coronary microembolization (CME) is associated with cardiomyocyte apoptosis and cardiac
dysfunction. Puerarin confers protection against multiple cardiovascular diseases, but its …

Objectives: The purpose of this study was to explore the effect of nicorandil on the incidence
of contrast-induced nephropathy in patients with coronary heart disease undergoing …

Coronary microembolization (CME)-induced inflammatory response and cardiomyocyte
apoptosis are the main contributors to CME-associated myocardial dysfunction. Bezafibrate …

Purpose: To examine the effect of nicorandil on high glucose-induced cardiomyocyte
inflammation and oxidative stress. Methods: H9C2 cardiomyocytes were divided into control …

Chronic postsurgical pain (CPSP) has a high incidence, but the underlying mechanism is
not well understood. Accumulating evidence has suggested that central sensitization is the …