The development of the radioimmunoassay for digoxin by Smith and coworkers in 1969 was
a landmark in digitalis therapy. Since then, the complex pharmacokinetics of digoxin have …

Digoxin toxicity remains a common medical problem for both adults and children. In addition
to a vastly improved understanding of the mechanisms for digoxin action on the heart, there …

Objective Atrial fibrillation is commonly treated with intravenously administered digoxin. The
main objective of this study was to investigate the relationship between plasma …

Profibrillatory Effects of Verapamil. Introduction: Verapamil and digoxin have been shown to
modulate tachycardia‐induced atrial electrical remodeling. The goal of the present study …

Objective: To review the pharmacodynamic and pharmacokinetic properties of digoxin in
health and disease and the potential use and toxic effects of digoxin in the critically ill …

Although digitalis preparations have been in use for> 200 years, it is only within the last 2
decades that the central hemodynamic and neurohumoral effects occurring over several …

Aim Little is known regarding the steady‐state uptake of drugs into the human myocardium.
Perhexiline is a prophylactic anti‐anginal drug which is increasingly also used in the …

Purpose. The purpose of this study was to construct a mechanistic pharmacokinetic/
pharmacodynamic (PK/PD) model for digoxin that describes the relationship between …

Introduction: Evaluation of kinetics of uptake into the heart could be important for the efficacy
and toxicity of cardioactive drugs. Although recent advances in molecular biology have …

Abstract□ We have recently reported the time course of acute myocardial drug uptake and
simultaneous pharmacodynamic effects for metoprolol (4 mg; n= 12) and sotalol (20 mg; n …