Abstract The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival,
proliferation, migration, metabolism and other vital cellular life processes. In addition …

Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …

Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …

The tumor microenvironment fuels tumorigenesis and induces the development of
resistance to anticancer drugs. A growing number of reports support that the tumor …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

Molecular mechanisms underlying cancer metastasis span diverse tissues of origin. Here,
we synthesize and collate the transcriptomes of patient-derived xenografts and patient tumor …

The mechanisms underlying ETS-driven prostate cancer initiation and progression remain
poorly understood due to a lack of model systems that recapitulate this phenotype. We …

We have performed a functional in vivo mutagenesis screen to identify genes that, when
altered, cooperate with a heterozygous Pten mutation to promote prostate tumour formation …

Prostate cancer (PCa) is today the second most common cancer in the world, with almost
400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older …

Abstract Pre-clinically, the mTORC1/2 inhibitor sapanisertib restored sensitivity to platinums
and enhanced paclitaxel-induced cancer cell killing. NCT03430882 enrolled patients with …