The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

The lungs are constantly exposed to environmental and infectious agents such as dust,
viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped …

Each tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a
central challenge of cancer therapeutics. Dozens of recent studies have begun to describe …

One key barrier to improving efficacy of personalized cancer immunotherapies that are
dependent on the tumor antigenic landscape remains patient stratification. Although patients …

Our skin contributes critically to health via its role as a barrier tissue, carefully regulating
passage of key substrates while also providing defense against exogenous threats …

Durable reconstitution of the distal lung epithelium with pluripotent stem cell (PSC)
derivatives, if realized, would represent a promising therapy for diseases that result from …

Understanding the molecular and cellular processes involved in lung epithelial regeneration
may fuel the development of therapeutic approaches for lung diseases. We combine mouse …

Metastatic cancer is difficult to treat and is responsible for the majority of cancer-related
deaths. After cancer cells initiate metastasis and successfully seed a distant site, resident …

The disease severity of coronavirus disease 2019 (COVID-19) varies considerably from
asymptomatic to serious, with fatal complications associated with dysregulation of innate …

Lung diseases rank third in terms of mortality and represent a significant economic burden
globally. Scientists have been conducting research to better understand respiratory …