Targeted overexpression of galanin in lactotrophs of transgenic mice induces hyperprolactinemia and pituitary hyperplasia

A Cai, JD Hayes, N Patel, JF Hyde - Endocrinology, 1999 - academic.oup.com
We generated transgenic mice that carry 4.6 kb of the mouse galanin gene fused to 2.5 kb of
the rat PRL promoter. In all transgenic lines that carried and transmitted the transgene, there …

Parental brain through time: The origin and development of the neural circuit of mammalian parenting

KO Kuroda, K Fukumitsu, T Kurachi… - Annals of the New …, 2024 - Wiley Online Library
This review consolidates current knowledge on mammalian parental care, focusing on its
neural mechanisms, evolutionary origins, and derivatives. Neurobiological studies have …

Endogenous galanin potentiates spinal nociceptive processing following inflammation

BJ Kerr, Y Gupta, R Pope, SWN Thompson, D Wynick… - Pain, 2001 - journals.lww.com
We have undertaken a series of experiments using galanin null mutant mice to better define
the role of endogenous galanin in spinal excitability following inflammation and in response …

Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain

O Cordero-Llana, F Rinaldi, PA Brennan, D Wynick… - Experimental …, 2014 - Elsevier
Galanin is a pleiotropic neuropeptide widely expressed in the nervous system. It plays a role
in many diverse physiological functions–including nociception, cognition and metabolism …

Endogenous galanin protects mouse hippocampal neurons against amyloid toxicity in vitro via activation of galanin receptor-2

CR Elliott-Hunt, FE Holmes, DM Hartley… - Journal of …, 2011 - content.iospress.com
Expression of the neuropeptide galanin is known to be upregulated in the brain of patients
with Alzheimer's disease (AD). We and others have shown that galanin plays a …

Key stages in mammary gland development-The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli …

SR Oakes, HN Hilton, CJ Ormandy - Breast Cancer Research, 2006 - Springer
Massive tissue remodelling occurs within the mammary gland during pregnancy, resulting in
the formation of lobuloalveoli that are capable of milk secretion. Endocrine signals …

Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse

I Neganova, H Al-Qassab, H Heffron… - Biology of …, 2007 - academic.oup.com
Insulin receptor signaling regulates female reproductive function acting in the central
nervous system and ovary. Female mice that globally lack insulin receptor substrate (IRS) 2 …

Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin

JG Hohmann, DN Teklemichael… - … and cellular biology, 2004 - Taylor & Francis
Neuropeptide Y (NPY) and galanin have both been implicated in the regulation of body
weight, yet mice bearing deletions of either of these molecules have unremarkable …

Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor

MM Gresle, H Butzkueven, VM Perreau, A Jonas… - Glia, 2015 - Wiley Online Library
In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC)
survival, we utilized microarrays to characterize changes in OC gene expression after …

Galanin receptor plasticity within the nucleus basalis in early and late Alzheimer's disease: an in vitro autoradiographic analysis

EJ Mufson, DC Deecher, M Basile, S Izenwasse… - …, 2000 - Elsevier
Hypertrophy of fibers containing galanin (GAL), the inhibitory neurotransmitter of
acetylcholine, occur on remaining cholinergic nucleus basalis neurons in late stage …