The human immune system is a complex network of coordinated components that are
crucial for health and disease. Animal models, commonly used to study immunomodulatory …

With the rapid development of three-dimensional (3D) bioprinting technology, the research
revolving around in vitro functional pancreas and tumor models has become the focus of …

Introduction Heparins, naturally occurring glycosaminoglycans, are widely used for
thrombosis prevention. Upon application as anticoagulants in cancer patients, heparins …

The strategies of future medicine are aimed to modernize and integrate quality approaches
including early molecular-genetic profiling, identification of new therapeutic targets and …

Immunotherapy represents a promising strategy for cancer treatment that utilizes immune
cells or drugs to activate the patient's own immune system and eliminate cancer cells. One of …

The tumor microenvironment (TME) assumes a pivotal role in the treatment of oncological
diseases, given its intricate interplay of diverse cellular components and extracellular …

Head and neck cancers (HNCs) rank as the sixth most common cancer globally and result in
over 450 000 deaths annually. Despite considerable advancements in diagnostics and …

Methods and results: In the present study, we discovered that heparin and its derivatives act
as potent, selective, allosteric inhibitors of the poorly investigated ectonucleotidase NPP1 …