Induced pluripotent stem cell‐derived extracellular vesicles: A novel approach for cell‐free regenerative medicine

B Taheri, M Soleimani, S Fekri Aval… - Journal of Cellular …, 2019 - Wiley Online Library
In recent years, induced pluripotent stem cells (iPSCs) have been considered as a
promising approach in the field of regenerative medicine. iPSCs can be generated from …

Exosomes derived from induced pluripotent stem cells suppresses M2-type macrophages during pulmonary fibrosis via miR-302a-3p/TET1 axis

Y Zhou, Y Gao, W Zhang, Y Chen, M Jin… - International …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (PF) is a type of chronic lung disease. Here, we investigated
the effect of induced pluripotent stem cell (iPSC)-derived exosomes (iPSC-exosomes) on M2 …

Anti-inflammatory drug candidates for prevention and treatment of cardiovascular diseases

Q Delbaere, N Chapet, F Huet, C Delmas, N Mewton… - Pharmaceuticals, 2023 - mdpi.com
Incidence and mortality rates for cardiovascular disease are declining, but it still remains a
major cause of morbidity and mortality. Drug treatments to slow the progression of …

[HTML][HTML] Safety and biodistribution of exosomes derived from human induced pluripotent stem cells

Z Gu, Z Yin, P Song, Y Wu, Y He, M Zhu… - … in Bioengineering and …, 2022 - frontiersin.org
As a new cell-free therapy, exosomes have provided new ideas for the treatment of various
diseases. Human induced pluripotent stem cells (hiPSCs) cannot be used in clinical trials …

Stem cell-derived extracellular vesicles for cancer therapy and tissue engineering applications

CS Lee, M Lee, K Na, HS Hwang - Molecular Pharmaceutics, 2023 - ACS Publications
Recently, stem cells and their secretomes have attracted great attention in biomedical
applications, particularly extracellular vesicles (EVs). EVs are secretomes of cells for cell-to …

Exosomes derived from MSC pre‐treated with oridonin alleviates myocardial IR injury by suppressing apoptosis via regulating autophagy activation

M Fu, D Xie, Y Sun, Y Pan, Y Zhang… - Journal of cellular …, 2021 - Wiley Online Library
This study aimed to investigate the molecular mechanisms underlying the role of bone
marrow mesenchymal stem cells (BMMSCs)‐derived exosomes in ischaemia/reperfusion …

Tanshinone IIA improves cardiac function via regulating miR-499-5p dependent angiogenesis in myocardial ischemic mice

X Wang, C Wu - Microvascular Research, 2022 - Elsevier
Background/aims Myocardial ischemia-reperfusion injury leads to aggravated cardiac
remodeling and heart failure. After myocardial infarction (MI), angiogenesis plays a vital role …

[HTML][HTML] Stem cell therapy for diabetic foot ulcers: Theory and practice

DL Nalisa, M Moneruzzaman, GJ Changwe… - Journal of Diabetes …, 2022 - hindawi.com
Diabetic foot ulcers are associated with increases in limb amputation, morbidity, and
mortality. Recently, a stem cell application is emerging as promising adjuvant therapy. We …

Different sourced extracellular vesicles and their potential applications in clinical treatments

L Bahmani, M Ullah - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) include a heterogeneous group of natural cell-derived
nanostructures that are increasingly regarded as promising biotherapeutic agents and drug …

Differential effects of extracellular vesicles of lineage-specific human pluripotent stem cells on the cellular behaviors of isogenic cortical spheroids

M Marzano, J Bejoy, MR Cheerathodi, L Sun, SB York… - Cells, 2019 - mdpi.com
Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall
physiological and pathological states of stem cells and tissues. Human induced pluripotent …