Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

A microfluidic device with 3-D hydrogel cell cultures has been developed to test the
cytotoxicity of anti-cancer drugs while reproducing multi-organ interactions. In this device, a …

Targeting of therapeutic agents to molecular markers expressed on the surface of cells
requiring clinical intervention holds promise to improve specificity of delivery, enhancing …

With advantageous features such as minimizing the cost, time, and sample size
requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from …

Abstract The Visual Predictive Check (VPC) is a valuable and supportive instrument for
evaluating model performance. However in its most commonly applied form, the method …

ABSTRACT A multi‐organ‐on‐a‐chip (MOC), also known as a human‐on‐a‐chip, aims to
simulate whole body response to drugs by connecting microscale cell cultures of multiple …

The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …

Solid tumors develop abnormally at spatial and temporal scales, giving rise to biophysical
barriers that impact anti-tumor chemotherapy. This may increase the expenditure and time …

Microscale cell culture platforms better mimic the in vivo cellular microenvironment than
conventional, macroscale systems. Microscale cultures therefore elicit a more authentic …