Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Immunity to invasive fungal diseases

A Casadevall - Annual review of immunology, 2022 - annualreviews.org
Invasive fungal diseases are rare in individuals with intact immunity. This, together with the
fact that there are only a few species that account for most mycotic diseases, implies a …

[HTML][HTML] Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

S Wang, W Li, P Zhang, Z Wang, X Ma, C Liu… - Journal of advanced …, 2022 - Elsevier
Introductions Excessive mechanical stress is closely associated with cell death in various
conditions. Exposure of chondrocytes to excessive mechanical loading leads to a catabolic …

Candida albicans can foster gut dysbiosis and systemic inflammation during HIV infection

SD Zaongo, J Ouyang, S Isnard, X Zhou… - Gut …, 2023 - Taylor & Francis
Candida albicans (C. albicans) is a ubiquitous fungal commensal component of the human
microbiota, and under certain circumstances, such as during an immunocompromised state …

[PDF][PDF] Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion

J Westman, J Plumb, A Licht, M Yang, S Allert… - Cell reports, 2022 - cell.com
Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading
hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin. To prevent cell …

Candidalysins are a new family of cytolytic fungal peptide toxins

JP Richardson, R Brown, N Kichik, S Lee, E Priest… - MBio, 2022 - Am Soc Microbiol
Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen.
Candidalysin is secreted by Candida albicans and is critical for driving infection and host …

Exploring the inflammatory pathogenesis of colorectal cancer

AA Khalyfa, S Punatar, R Aslam, A Yarbrough - Diseases, 2021 - mdpi.com
Colorectal cancer is one of the most commonly diagnosed cancers worldwide. Traditionally,
mechanisms of colorectal cancer formation have focused on genetic alterations including …

[HTML][HTML] Is Candida albicans a contributor to cancer? A critical review based on the current evidence

X Wang, W Zhang, W Wu, S Wu, A Young… - Microbiological Research, 2023 - Elsevier
The association between Candida albicans (C. albicans) and cancer has been noticed for
decades. Whether C. albicans infection is a complication of cancer status or as a contributor …

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties

CM Russell, JA Rybak, J Miao, BM Peters… - Journal of Biological …, 2023 - ASBMB
Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic
infections per year. The pathobiology of C. albicans is largely dependent on the damaging …

Evaluation of a novel synthetic peptide derived from cytolytic mycotoxin candidalysin

PHO Cardoso, APA Boleti, PS Silva, LTH Mukoyama… - Toxins, 2022 - mdpi.com
The importance of neuroinflammation in neurology is becoming increasingly apparent. In
addition to neuroinflammatory diseases such as multiple sclerosis, the role of …