Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

H Scholz, FJ Boivin, KM Schmidt-Ott… - Nature Reviews …, 2021 - nature.com
Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

[HTML][HTML] The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - … and Targeted Therapy, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

[HTML][HTML] PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome …

Q Lin, S Li, N Jiang, X Shao, M Zhang, H Jin, Z Zhang… - Redox biology, 2019 - Elsevier
Contrast-induced acute kidney injury (CI-AKI) occurs in more than 30% of patients after
intravenous iodinated contrast media and causes serious complications, including renal …

Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy

Q Lin, S Li, N Jiang, H Jin, X Shao, X Zhu, J Wu… - Autophagy, 2021 - Taylor & Francis
The pathogenetic mechanism of contrast-induced acute kidney injury (CI-AKI), which is the
third most common cause of hospital-acquired AKI, has not been elucidated. Previously, we …

A lipid droplet-specific NIR fluorescent probe with a large stokes shift for in vivo visualization of polarity in contrast-induced acute kidney Injury

J Zhang, W Han, X Zhou, X Zhang, H Zhang… - Analytical …, 2023 - ACS Publications
The research on lipid droplets (LDs) has attracted great attention in the field of biomedical
science in recent years. LD malfunction is found to be associated with the development of …

Immunopathophysiology of trauma-related acute kidney injury

DAC Messerer, R Halbgebauer, B Nilsson… - Nature Reviews …, 2021 - nature.com
Physical trauma can affect any individual and is globally accountable for more than one in
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …

Renal-clearable probe with water solubility and photostability for biomarker-activatable detection of acute kidney injuries via NIR-II fluorescence and optoacoustic …

C Zeng, Y Tan, L Sun, Y Long, F Zeng… - ACS Applied Materials & …, 2023 - ACS Publications
Acute kidney injuries (AKI) have serious short-term or long-term complications with high
morbidity and mortality rate, thus posing great health threats. Developing high-performance …

A Renal‐Clearable Duplex Optical Reporter for Real‐Time Imaging of Contrast‐Induced Acute Kidney Injury

J Huang, Y Lyu, J Li, P Cheng, Y Jiang… - Angewandte …, 2019 - Wiley Online Library
Despite its high morbidity and mortality, contrast‐induced acute kidney injury (CIAKI)
remains a diagnostic dilemma because it relies on in vitro detection of insensitive late‐stage …

[HTML][HTML] Mitophagy in acute kidney injury and kidney repair

Y Wang, J Cai, C Tang, Z Dong - Cells, 2020 - mdpi.com
Acute kidney injury (AKI) is a major kidney disease characterized by rapid decline of renal
function. Besides its acute consequence of high mortality, AKI has recently been recognized …

[HTML][HTML] Systemic immune-inflammation index predicts contrast-induced acute kidney injury in patients undergoing coronary angiography: a cross-sectional study

H Jiang, D Li, T Xu, Z Chen, Y Shan, L Zhao… - Frontiers in …, 2022 - frontiersin.org
Background and aims: Systemic immune-inflammation index (SII) is an emerging indicator
and correlated to the incidence of cardiovascular diseases. This study aimed to explore the …