The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …

Background Prostate cancer continues to be the most common lethal malignancy diagnosed
in American men and the second leading cause of male cancer mortality. The American …

Proteins encoded by bcl-2 family genes are important regulators of programmed cell death
and apoptosis. Alterations in the expression of these apoptosis-regulating genes can …

Background MicroRNAs (miRNAs), some of which function as oncogenes or tumor
suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell …

The European Association of Urology (EAU) Guidelines Group for Prostate Cancer have
prepared this guidelines document to assist medical professionals assess the evidence …

OBJECTIVES:: The first summary of the European Association of Urology (EAU) guidelines
on prostate cancer was published in 2001. These guidelines have been continuously …

Cells possess within their epigenetic repertoire the ability to undergo an active process of
cellular suicide termed programmed (or apoptotic) cell death. This programmed cell death …