Antiapoptotic members of the Bcl-2 family proteins are overexpressed in prostate cancer and
are promising molecular targets for modulating chemoresistance of prostate cancer.(-) …

BREAST cancer is the most common malignancy among females in North America. Statistics
show that in the United States alone, about 200,000 new cases are diagnosed every year …

Members of the Bcl-2 family of proteins are crucial regulators of programmed cell death or
apoptosis. This family of proteins now includes both anti-apoptotic molecules such as Bcl-2 …

BACKGROUND Prostate cancer is the most commonly diagnosed neoplasm and the second
leading cause of male death in this country. Multiple genetic and epigenetic factors have …

Radioresistance markedly impairs the efficacy of tumor radiotherapy and involves
antiapoptotic signal transduction pathways that prevent radiation-induced cell death. The …

Although prostate cancer cells are often initially sensitive to androgen ablation, they
eventually lose this response and continue to survive, grow and spread in the absence of …

The ability of a tumor cell population to grow exponentially represents an imbalance
between cellular proliferation and cellular attrition. There is an overwhelming body of …

Bcl‐2 protein has been shown to contribute to oncogenesis because it can transform and
immortalize cells in cooperation with c‐myc, ras, or viral genes. However, in vivo studies …

Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule
assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have …

Migration and invasion of malignant cells are prerequisites for cancer progression and
metastasis. The Bcl-2 family of proteins consists of about 25 members and has been …