Most prostate cancers are androgen-dependent and essentially respond to androgen
ablation therapy. However, these tumors eventually become androgen-independent and …

Purpose: We determined the prognostic value of oncoprotein bcl-2 and androgen receptor
expression in pretreatment transurethral resection specimens of hormonally treated prostate …

BACKGROUND The expression of bcl‐2 has been studied extensively in a variety of human
tumors. However, there is a lack of clinical data regarding its expression in germ cell …

The BH3 mimetic (−)‐gossypol (−)‐G has shown promising efficacy to kill several kinds of
cancer cells or potentiate current chemotherapeutics. But it induces limited apoptosis in …

The primary form of therapy for prostate cancer is androgen ablation resulting in apoptosis
and expression of apoptotic genes (ie par-4). Prostate cancer cells that survive androgen …

Introduction Overexpression of antiapoptotic B-cell lymphoma (Bcl-2) proteins confers the
dysregulation of apoptosis and results in drug resistance in a variety of cancers, including …

Progression of prostate cancer to androgen independence remains the primary obstacle to
improved survival. The development of more effective treatments depends on our …

Publisher Summary This chapter describes the Bcl-2 family proteins and the hormonal
control of cell life and death in normalcy and neoplasia. These proteins regulate a distal step …

Molecular studies have suggested that ethnicity may play a significant role in prostate
tumorigenesis, but no information exists for groups other than Caucasian or Japanese …

Background Loss of contact with the extracellular matrix (ECM) triggers a specialized form of
apoptosis known as “anoikis” in normal epithelial cells. Dependence on adhesion to ECM is …