Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer's disease

N Yan, XL Shi, LQ Tang, DF Wang, X Li… - Journal of Enzyme …, 2022 - Taylor & Francis
Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in
the Alzheimer's disease (AD) pathology. A series of novel thieno [3, 2-c] pyrazol-3-amine …

[HTML][HTML] Alzheimer's disease: The past, present, and future of a globally progressive disease

B Vejandla, S Savani, R Appalaneni, RS Veeravalli… - Cureus, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a significant 21st-century public health challenge. This article
delves into AD's neurodegenerative complexities, highlighting cognitive decline, memory …

Role of multi-targeted bioactive natural molecules and their derivatives in the treatment of Alzheimer's disease: an insight into structure-activity relationship

D Halder, S Das, J RS, A Joseph - Journal of Biomolecular …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a complex neurodegenerative disorder involving cognitive
dysfunction like short-term memory and behavioral changes as the disease progresses due …

[HTML][HTML] Selenium-containing compounds: a new hope for innovative treatments in Alzheimer's disease and Parkinson's disease

P Pyka, S Garbo, R Fioravanti, C Jacob, M Hittinger… - Drug Discovery …, 2024 - Elsevier
Neurodegenerative diseases are challenging to cure. To date, no cure has been found for
Alzheimer's disease or Parkinson's disease, and current treatments are able only to slow the …

The protective effects of policosanol on learning and memory impairments in a male rat model of Alzheimer's Disease

S Safari, N Mirazi, N Ahmadi, M Asadbegi… - Molecular …, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by a
progressive decline in cognitive performance and memory formation. The present study was …

Relation between apolipoprotein e in alzheimer's disease and Sars-CoV-2 and their treatment strategy: A review

AK Ramachandran, S Das, GG Shenoy… - CNS & Neurological …, 2024 - ingentaconnect.com
COVID-19, which primarily affects the pulmonary system, turned out to be a global
pandemic, whereas the effects on other systems are still unknown. SARS-CoV-2, binds to …

MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review

HMH Azam, RI Rößling, C Geithe, MM Khan… - Frontiers in Molecular …, 2024 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …

Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease

Y Cui, X Zhang, J Liu, Y Hou, Q Song, M Cao… - Aging …, 2024 - Wiley Online Library
Amyloid plaques, a major pathological hallmark of Alzheimer's disease (AD), are caused by
an imbalance between the amyloidogenic and non‐amyloidogenic pathways of amyloid …

Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model

T Huang, X Gong, Z Liang, R Yang, L Wu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and moderate
exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive …

An insight into structure-activity relationship of naturally derived biological macromolecules for the treatment of Alzheimer's disease: a review

D Halder, S Das, A Joseph - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a neurological disorder that affects millions of people worldwide.
There are currently no cures for AD, although various drugs are used to manage the …