Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer's disease
N Yan, XL Shi, LQ Tang, DF Wang, X Li… - Journal of Enzyme …, 2022 - Taylor & Francis
Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in
the Alzheimer's disease (AD) pathology. A series of novel thieno [3, 2-c] pyrazol-3-amine …
the Alzheimer's disease (AD) pathology. A series of novel thieno [3, 2-c] pyrazol-3-amine …
[HTML][HTML] Alzheimer's disease: The past, present, and future of a globally progressive disease
B Vejandla, S Savani, R Appalaneni, RS Veeravalli… - Cureus, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a significant 21st-century public health challenge. This article
delves into AD's neurodegenerative complexities, highlighting cognitive decline, memory …
delves into AD's neurodegenerative complexities, highlighting cognitive decline, memory …
Role of multi-targeted bioactive natural molecules and their derivatives in the treatment of Alzheimer's disease: an insight into structure-activity relationship
Alzheimer's disease (AD) is a complex neurodegenerative disorder involving cognitive
dysfunction like short-term memory and behavioral changes as the disease progresses due …
dysfunction like short-term memory and behavioral changes as the disease progresses due …
[HTML][HTML] Selenium-containing compounds: a new hope for innovative treatments in Alzheimer's disease and Parkinson's disease
Neurodegenerative diseases are challenging to cure. To date, no cure has been found for
Alzheimer's disease or Parkinson's disease, and current treatments are able only to slow the …
Alzheimer's disease or Parkinson's disease, and current treatments are able only to slow the …
The protective effects of policosanol on learning and memory impairments in a male rat model of Alzheimer's Disease
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by a
progressive decline in cognitive performance and memory formation. The present study was …
progressive decline in cognitive performance and memory formation. The present study was …
Relation between apolipoprotein e in alzheimer's disease and Sars-CoV-2 and their treatment strategy: A review
COVID-19, which primarily affects the pulmonary system, turned out to be a global
pandemic, whereas the effects on other systems are still unknown. SARS-CoV-2, binds to …
pandemic, whereas the effects on other systems are still unknown. SARS-CoV-2, binds to …
MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
HMH Azam, RI Rößling, C Geithe, MM Khan… - Frontiers in Molecular …, 2024 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …
Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease
Y Cui, X Zhang, J Liu, Y Hou, Q Song, M Cao… - Aging …, 2024 - Wiley Online Library
Amyloid plaques, a major pathological hallmark of Alzheimer's disease (AD), are caused by
an imbalance between the amyloidogenic and non‐amyloidogenic pathways of amyloid …
an imbalance between the amyloidogenic and non‐amyloidogenic pathways of amyloid …
Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model
T Huang, X Gong, Z Liang, R Yang, L Wu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and moderate
exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive …
exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive …
An insight into structure-activity relationship of naturally derived biological macromolecules for the treatment of Alzheimer's disease: a review
Alzheimer's disease (AD) is a neurological disorder that affects millions of people worldwide.
There are currently no cures for AD, although various drugs are used to manage the …
There are currently no cures for AD, although various drugs are used to manage the …