The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
Schizophrenia: a narrative review of etiopathogenetic, diagnostic and treatment aspects
L Orsolini, S Pompili, U Volpe - Journal of Clinical Medicine, 2022 - mdpi.com
Although schizophrenia is currently conceptualized as being characterized as a syndrome
that includes a collection of signs and symptoms, there is strong evidence of heterogeneous …
that includes a collection of signs and symptoms, there is strong evidence of heterogeneous …
Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview
A Choudhary, D Peles, R Nayak, L Mizrahi… - Schizophrenia Research, 2022 - Elsevier
Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …
disables the patients as well as decreases their life expectancy and quality of life. Common …
Microglia at the tripartite synapse during postnatal development: Implications for autism spectrum disorders and schizophrenia
L Ferrucci, I Cantando, F Cordella, S Di Angelantonio… - Cells, 2023 - mdpi.com
Synapses are the fundamental structures of neural circuits that control brain functions and
behavioral and cognitive processes. Synapses undergo formation, maturation, and …
behavioral and cognitive processes. Synapses undergo formation, maturation, and …
Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia
Besides playing a central role in neuroinflammation, microglia regulate synaptic
development and is involved in plasticity. Converging lines of evidence suggest that these …
development and is involved in plasticity. Converging lines of evidence suggest that these …
Immune-related genomic schizophrenic subtyping identified in DLPFC transcriptome
Well-documented evidence of the physiologic, genetic, and behavioral heterogeneity of
schizophrenia suggests that diagnostic subtyping may clarify the underlying pathobiology of …
schizophrenia suggests that diagnostic subtyping may clarify the underlying pathobiology of …
Disclosing common biological signatures and predicting new therapeutic targets in schizophrenia and obsessive–compulsive disorder by integrated bioinformatics …
A Ghanbarzehi, A Sepehrinezhad, N Hashemi… - BMC psychiatry, 2023 - Springer
Schizophrenia (SCZ) is a severe mental illness mainly characterized by a number of
psychiatric symptoms. Obsessive–compulsive disorder (OCD) is a long-lasting and …
psychiatric symptoms. Obsessive–compulsive disorder (OCD) is a long-lasting and …
Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature …
A Torsvik, HR Brattbakk, A Trentani, R Holdhus… - Translational …, 2023 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic
susceptibility, and immune alterations. We aimed to identify differential transcriptional …
susceptibility, and immune alterations. We aimed to identify differential transcriptional …
Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review
Following the recent review by Merikangas et al.[1] summarizing differential gene
expression in schizophrenia, we wanted to provide readers with our perspective on the state …
expression in schizophrenia, we wanted to provide readers with our perspective on the state …
Infections, inflammation, and psychiatric illness: review of postmortem evidence
MJ Webster - Microorganisms and Mental Health, 2022 - Springer
While there is an abundance of epidemiological evidence implicating infectious agents in
the etiology of severe mental illnesses, postmortem studies have not yet detected an …
the etiology of severe mental illnesses, postmortem studies have not yet detected an …