Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …

Ferroptosis is an iron-dependent form of programmed cell death driven by excessive
oxidation of polyunsaturated phospholipids on cellular membranes. Accumulating evidence …

Ethnopharmacological relevance Hypertensive nephropathy (HN) is a complication of
hypertension. Taohongsiwu decoction (THSWD) is used clinically but its application in the …

Background With the increasing prevalence of hypertension, diabetes, and obesity, the
incidence of kidney diseases is also increasing, resulting in a serious public burden …

Mitochondria are vital for energy production and redox homeostasis, yet knowledge of
relevant mechanisms remains limited. Here, through a genome-wide CRISPR-Cas9 …

Ferroptosis, a regulated form of cell death, is characterized by iron-dependent lipid
peroxidation leading to oxidative damage to cell membranes. Cell sensitivity to ferroptosis is …

Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence
rate worldwide, is characterized by a rapid deterioration of renal function and further triggers …

Diabetic kidney disease (DKD) is one of the most common and severe microvascular
complications of diabetes mellitus (DM), and has become the leading cause of end-stage …

According to recent evidence, ferroptosis is a major cell death mechanism in the
pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical …

Ferroptosis is an iron-dependent programmed cell death pattern that is characterized by iron
overload, reactive oxygen species (ROS) accumulation and lipid peroxidation. Growing …