Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets

Y Cai, J Liu, B Wang, M Sun, H Yang - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

M Xue, VW Yong - The Lancet Neurology, 2020 - thelancet.com
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Y Wang, M Tian, J Tan, X Pei, C Lu, Y Xin… - Journal of …, 2022 - Springer
Background Neuroinflammation is a crucial factor in the development of secondary brain
injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers …

Neuroinflammation in acute ischemic and hemorrhagic stroke

DL Alsbrook, M Di Napoli, K Bhatia, J Biller… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review This review aims to provide an overview of neuroinflammation
in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and …

Behavioral assessment of sensory, motor, emotion, and cognition in rodent models of intracerebral hemorrhage

X Shi, H Bai, J Wang, J Wang, L Huang, M He… - Frontiers in …, 2021 - frontiersin.org
Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of
the highest fatality rates of any disease. There are many clinical signs and symptoms after …

[HTML][HTML] Brain edema formation and therapy after intracerebral hemorrhage

Y Wan, KG Holste, Y Hua, RF Keep, G Xi - Neurobiology of disease, 2023 - Elsevier
Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

Microglia in Alzheimer's disease: Pathogenesis, mechanisms, and therapeutic potentials

J Miao, H Ma, Y Yang, Y Liao, C Lin, J Zheng… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

The role of microglia in Alzheimer's disease from the perspective of immune inflammation and iron metabolism

HZ Long, ZW Zhou, Y Cheng, HY Luo, FJ Li… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: an update

H Ren, R Han, X Chen, X Liu, J Wan… - Journal of Cerebral …, 2020 - journals.sagepub.com
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

An insight of interleukin-6 and fibrinogen: in regulating the immune system

EI Obeagu, E Muhimbura, B Pahari, S Nakyeyune… - 2022 - ir.kiu.ac.ug
The role of the liver as a critical part of the immune system involved in both innate and
adaptive immunity. As a major source of acute phase proteins, including components of the …