Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …

The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

Introduction Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated
with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC). E-Cadherin …

Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation
and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. IKZF1 …

Regenerative medicine is predicated on understanding the mechanisms regulating
development and applying these conditions to direct stem cell fate. Embryogenesis is …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Epithelial tissues are defined by polarized epithelial cells that are integrated into tissues and
exhibit barrier function in order to regulate what is allowed to pass between cells. Cell-cell …