Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar

QM Pang, SY Chen, QJ Xu, SP Fu, YC Yang… - Frontiers in …, 2021 - frontiersin.org
Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …

Scaled preparation of extracellular vesicles from conditioned media

S Staubach, FN Bauer, T Tertel, V Börger… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are
increasingly considered as biotherapeutic agents for a variety of different diseases. For …

[HTML][HTML] Bioengineered MSC-derived exosomes in skin wound repair and regeneration

H Zhao, Z Li, Y Wang, K Zhou, H Li, S Bi… - Frontiers in Cell and …, 2023 - frontiersin.org
Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers
represent a challenge for clinicians and researchers in many aspects. The treatment …

Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury

N Labusek, Y Mouloud, C Köster, E Diesterbeck… - Inflammation and …, 2023 - Springer
Background Human mesenchymal stromal cell (MSC)-derived extracellular vesicles (EV)
revealed neuroprotective potentials in various brain injury models, including neonatal …

Perinatal hyperoxia and developmental consequences on the lung‐brain axis

S Obst, J Herz, MA Alejandre Alcazar… - Oxidative medicine …, 2022 - Wiley Online Library
Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal
intensive care significantly increased survival rates over the last decades but failed to …

Peripheral immune cells and perinatal brain injury: a double-edged sword?

J Herz, I Bendix, U Felderhoff-Müser - Pediatric Research, 2022 - nature.com
Perinatal brain injury is the leading cause of neurological mortality and morbidity in
childhood ranging from motor and cognitive impairment to behavioural and neuropsychiatric …

Harnessing the therapeutic potential of the stem cell secretome in neonatal diseases

S Tung, E Delavogia, A Fernandez-Gonzalez… - Seminars in …, 2023 - Elsevier
Preterm birth and intra-partum related complications account for a substantial amount of
mortality and morbidity in the neonatal period despite significant advancements in neonatal …

Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)

EJ Molloy, M El-Dib, J Soul, S Juul, AJ Gunn… - Pediatric …, 2024 - nature.com
The survival of preterm infants has steadily improved thanks to advances in perinatal and
neonatal intensive clinical care. The focus is now on finding ways to improve morbidities …

[HTML][HTML] Reactive astrocytes in central nervous system injury: subgroup and potential therapy

GL Yu, Y Zhang, B Ning - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Traumatic central nervous system (CNS) injury, which includes both traumatic brain injury
(TBI) and spinal cord injury (SCI), is associated with irreversible loss of neurological function …

[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …