Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (ie they are no
longer able to divide) and perform muscle contraction. They are formed by fusion of muscle …

Research into fundamental principles and the testing of therapeutic hypotheses for treatment
of human disease is commonly performed on mouse models of human diseases. Although …

Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in
breaches of the plasma membrane and chronic inflammation in Duchenne muscular …

The muscular dystrophies comprise more than 30 clinical disorders that are characterized by
progressive skeletal muscle wasting and degeneration. Although the genetic basis for many …

Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin
(DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and …

Ferlins are a family of multiple C 2 domain proteins with emerging roles in vesicle fusion and
membrane trafficking. Ferlin mutations are associated with muscular dystrophy (dysferlin) …

Many neuromuscular disorders can have a differential impact on a specific myofibre type,
forming the central premise of this review. The many different skeletal muscles in mammals …

Background Fibrosis, an excessive collagen accumulation, results in scar formation,
impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies …

Duchenne muscular dystrophy (DMD), an incurable and a progressive muscle wasting
disease, is caused by the absence of dystrophin protein, leading to recurrent muscle fiber …

Dysferlin is a membrane associated protein involved in vesicle trafficking and fusion. Defects
in dysferlin result in limb-girdle muscular dystrophy type 2B and Miyoshi myopathy in …