Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …

Multitargeting compounds comprising activity on more than a single biological target have
gained remarkable relevance in drug discovery owing to the complexity of multifactorial …

To develop the next-generation Pt drug with remarkable activity and low toxicity to maximally
inhibit tumor growth, we optimized a Pt (II) thiosemicarbazone compound (C4) with …

Drug combinations have demonstrated great potential in cancer treatments. They alleviate
drug resistance and improve therapeutic efficacy. The fast-growing number of anti-cancer …

Cancer is a deadly disease. There is no drug yet for the treatment of some types of cancer.
New drug trials are being conducted to treat this disease. One of them is HDAC‐based multi …

Using a single drug to treat cancer with dual-targeting is an unusual approach when
compared to other drug combinations. Dual-targeting agents were developed as a result of …

In the past decades, triptolide has attracted considerable interests in the organic and
medicinal chemistry society owing to its intriguing structure features and promising multiple …

Due to the multimodal character of cancer, inhibition of two targets simultaneously by a
single molecule is a beneficial and effective approach against cancer. Histone deacetylase …

Two new classes of hybrid quinoline–imidazole/benzimidazole derivatives (the hybrid QIBS
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …