Heat shock protein 90, also known as Hsp90, is an extensively preserved molecular
chaperone that performs a critical function in organizing various biological pathways and …

Lung cancer is the second most common cause of morbidity and mortality among cancer
types worldwide, with non-small cell lung cancer (NSCLC) representing the majority of most …

de novo Drug Design (dnDD) aims to create new molecules that satisfy multiple conflicting
objectives. Since several desired properties can be considered in the optimization process …

The discovery of therapeutic molecules is fundamentally a multi-objective optimization
problem. One formulation of the problem is to identify molecules that simultaneously exhibit …

The success of innovative drugs depends on an interdisciplinary and holistic approach to
their design and development. The supramolecular architecture of living systems is …

Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel
strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an …

To overcome the limitations of traditional platinum (Pt)-based drugs and further improve the
targeting ability and therapeutic efficacy in vivo, we proposed to design a human serum …

Histone deacetylase inhibitors (HDACIs) are responsible for controlling gene expression by
modulating the acetylation status of histone proteins. Furthermore, they modulate the activity …

Mounting evidence suggests that strategies combining DNA-damaging agents and
stimulator of interferon genes (STING) agonists are promising cancer therapeutic regimens …

To combat multifactorial refractory diseases, such as cancer, cardiovascular, and
neurodegenerative diseases, multitarget drugs have become an emerging area of research …