Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells)
MK Abdelhameid, I Zaki, MR Mohammed… - Bioorganic …, 2020 - Elsevier
Novel azole derivatives 3–30 were designed, synthesized, and screened for their antitumor
activity on HepG2 cell line. The cytotoxicity screening demonstrated that imidazolone 8 and …
activity on HepG2 cell line. The cytotoxicity screening demonstrated that imidazolone 8 and …
Amygdalin as multi-target anticancer drug against targets of cell division cycle: Double docking and molecular dynamics simulation
K Al-Khafaji, T Taskin Tok - Journal of Biomolecular Structure and …, 2021 - Taylor & Francis
Cell-division protein kinases (CDKs) are gorgeous examples of targets for the helpful
treatment of cancer by using multi-target inhibitors. Specifically, targeting cell-division …
treatment of cancer by using multi-target inhibitors. Specifically, targeting cell-division …
Double-edged swords: diaryl pyrazoline thiazolidinediones synchronously targeting cancer epigenetics and angiogenesis
In the present study, two novel series of compounds incorporating naphthyl and pyridyl
linker were synthesized and biological assays revealed 5-((6-(2-(5-(2-chlorophenyl)-3-(4 …
linker were synthesized and biological assays revealed 5-((6-(2-(5-(2-chlorophenyl)-3-(4 …
Structure optimization, synthesis, and biological evaluation of 6-(2-amino-1H-benzo [d] imidazole-6-yl)-quinazolin-4 (3H)-one derivatives as potential multi-targeted …
Y Fan, F Luo, M Su, Q Li, T Zhong, L Xiong, M Li… - Bioorganic …, 2023 - Elsevier
Abstract Aurora A (Aurora kinase A), a critical regulator of cell mitosis, is frequently
overexpressed in many malignant cancers, and has been considered as a promising drug …
overexpressed in many malignant cancers, and has been considered as a promising drug …
[HTML][HTML] MV1035 overcomes temozolomide resistance in patient-derived glioblastoma stem cell lines
A Malacrida, A Di Domizio, A Bentivegna, G Cislaghi… - Biology, 2022 - mdpi.com
Simple Summary Since 2005, temozolomide (TMZ) has been used as a standard first-line
treatment for glioblastoma (GBM, grade IV glioma), and despite many studies and efforts no …
treatment for glioblastoma (GBM, grade IV glioma), and despite many studies and efforts no …
Multi-target-based polypharmacology prediction (mTPP): an approach using virtual screening and machine learning for multi-target drug discovery
K Liu, X Chen, Y Ren, C Liu, T Lv, Y Zhang - Chemico-Biological …, 2022 - Elsevier
Polypharmacology has become a new paradigm in drug discovery and plays an
increasingly vital role in discovering multi-target drugs. In this context, multi-target drugs are …
increasingly vital role in discovering multi-target drugs. In this context, multi-target drugs are …
Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors
Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a–f and oxo-
selaneylidene moiety 4, besides selenadiazolopyrimidines (5a–e and 7), were synthesised …
selaneylidene moiety 4, besides selenadiazolopyrimidines (5a–e and 7), were synthesised …
Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline–benzenesulfonamide derivatives harboring phenol/polyphenol moieties
In this study, phenol and benzenesulfonamide substituted pyrazoline derivative novel
compounds (1a–14a) were synthesized successfully for the first time (except 3a, 8a, 13a …
compounds (1a–14a) were synthesized successfully for the first time (except 3a, 8a, 13a …
Appendix A. dithioloquinolinethiones as new potential multitargeted antibacterial and antifungal agents: Synthesis, biological evaluation and molecular docking …
V Kartsev, KS Shikhaliev, A Geronikaki… - European Journal of …, 2019 - Elsevier
Herein we report the design, synthesis, molecular docking study and evaluation of
antimicrobial activity of ten new dithioloquinolinethiones. The structures of compounds were …
antimicrobial activity of ten new dithioloquinolinethiones. The structures of compounds were …
[HTML][HTML] Anticancer function and ROS-mediated multi-targeting anticancer mechanisms of copper (II) 2-hydroxy-1-naphthaldehyde complexes
Multi-targeting of oncoproteins by a single molecule represents an effectual, rational, and an
alternative approach to target therapy. We carried out a systematic study to reveal the …
alternative approach to target therapy. We carried out a systematic study to reveal the …