[HTML][HTML] Improved outcomes with enzalutamide in biochemically recurrent prostate cancer

SJ Freedland, M de Almeida Luz… - … England Journal of …, 2023 - Mass Medical Soc
Background Patients with prostate cancer who have high-risk biochemical recurrence have
an increased risk of progression. The efficacy and safety of enzalutamide plus androgen …

[HTML][HTML] Gynecomastia: etiology, diagnosis, and treatment

RS Swerdloff, JCM Ng - Endotext [Internet], 2023 - ncbi.nlm.nih.gov
Gynecomastia is a relatively common disorder. Its causes range from benign physiological
processes to rare neoplasms. To diagnose the etiology of the gynecomastia, the clinician …

[HTML][HTML] State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer

S Ramesh, P Selvakumar, MY Ameer, S Lian… - Frontiers in …, 2023 - frontiersin.org
Newer therapeutic strategies on rise for Prostate Cancer stem cells due to current
standardized therapies for prostate cancer including chemotherapy, androgen deprivation …

[HTML][HTML] Prostate specific antigen

MK David, SW Leslie - 2020 - europepmc.org
The primary reason for the utilization of any screening exam should be that the procedure
detects the early stages of a pathologic condition and allows for early intervention, thereby …

Role of enzalutamide in primary and recurrent non-metastatic hormone sensitive prostate cancer: a systematic review of prospective clinical trials

M Shelan, V Achard, F Appiagyei, L Mose… - Prostate cancer and …, 2024 - nature.com
Introduction Enzalutamide, a second-generation androgen receptor inhibitor, is indicated for
the treatment of metastatic disease, as well as in the treatment of non-metastatic castration …

Risk stratification of low-risk prostate cancer: individualizing care in the era of active surveillance

MD Ho, AE Ross, SE Eggener - Journal of Urology, 2023 - journals.lww.com
Purpose: While active surveillance is the preferred management for most men with low-risk
prostate cancer, a subset may harbor more aggressive disease. In this review we examine …

A phase 2, double-blind, randomized controlled trial of PROSTVAC in prostate cancer patients on active surveillance

JK Parsons, PA Pinto, CP Pavlovich, E Uchio… - European Urology …, 2023 - Elsevier
Background There is an unmet clinical need for interventions to prevent disease progression
in patients with localized prostate cancer on active surveillance (AS). Objective To determine …

A multivalent peptoid conjugate modulates androgen receptor transcriptional activity to inhibit therapy-resistant prostate cancer

J Habault, JA Schneider, S Ha, R Ruoff… - Molecular Cancer …, 2023 - AACR
Prostate cancers adapt to androgen receptor (AR) pathway inhibitors and progress to
castration resistance due to ongoing AR expression and function. To counter this, we …

[HTML][HTML] Nonsurgical Interventions to Prevent Disease Progression in Prostate Cancer Patients on Active Surveillance: A Systematic Review and Meta-analysis

A Matsukawa, T Yanagisawa, K Bekku… - European Urology …, 2023 - Elsevier
Context Active surveillance (AS) is a standard of care for patients with low-risk and selected
intermediate-risk prostate cancer (PCa). Nevertheless, there is a lack of summary evidence …

Antiandrogen Treatment vs Active Surveillance for Patients With Prostate Cancer—Reply

ND Shore, MR Cooperberg, SA Tomlins - JAMA oncology, 2023 - jamanetwork.com
In Reply Active surveillance (AS) is the preferred management strategy for low-risk prostate
cancer. While AS rates are increasing in clinical practice, its adoption remains suboptimal …