The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS
wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is …

Spinal cord injury (SCI) is a devastating trauma that leads to irreversible motor and sensory
dysfunction and is, so far, without effective treatment. Recently, however, nano‐sized …

Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the
immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated …

The mesenchymal (MES) subtype of glioblastoma (GBM) is a highly aggressive, malignant
and proliferative cancer that is resistant to chemotherapy. Runt-related transcription factor 1 …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). Its etiology is unclear.
Much evidence suggests that the death of abnormal intestinal epithelial cells (IECs) leads to …

Simple Summary This review summarizes the current DUBs findings that correlate with the
most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung …

Plenty of factors affect the oncogenesis and progression of colorectal cancer in the tumor
microenvironment, including various immune cells, stromal cells, cytokines, and other …