A new era for understanding amyloid structures and disease
MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
[HTML][HTML] The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
A guide to studying protein aggregation
JAJ Housmans, G Wu, J Schymkowitz… - The FEBS …, 2023 - Wiley Online Library
Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …
Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …
Previous research has established amyloid plaque deposition as the leading cause of …
[HTML][HTML] Atomic force microscopy for single molecule characterisation of protein aggregation
The development of atomic force microscopy (AFM) has opened up a wide range of novel
opportunities in nanoscience and new modalities of observation in complex biological …
opportunities in nanoscience and new modalities of observation in complex biological …
Lipids uniquely alter rates of insulin aggregation and lower toxicity of amyloid aggregates
Amyloid formation is a hallmark of many medical diseases including diabetes type 2,
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …
Unsaturation in the fatty acids of phospholipids drastically alters the structure and toxicity of insulin aggregates grown in their presence
M Matveyenka, S Rizevsky… - The journal of physical …, 2022 - ACS Publications
Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …
Complete aggregation pathway of amyloid β (1-40) and (1-42) resolved on an atomically clean interface
To visualize amyloid β (Aβ) aggregates requires an uncontaminated and artifact-free
interface. This paper demonstrates the interface between graphene and pure water (verified …
interface. This paper demonstrates the interface between graphene and pure water (verified …
The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates
M Matveyenka, S Rizevsky, D Kurouski - FEBS letters, 2022 - Wiley Online Library
Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …