The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …

Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Cell-to-cell communication is essential for the development and proper function of
multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) …

Parkinson's disease (PD) is one of the most common and chronic degenerative diseases in
the central nervous system. The main pathology of PD formation is the progressive loss of …

The gut microbiota influence neurodevelopment, modulate behavior, and contribute to
neurodegenerative disorders. Several studies have consistently reported a greater …

Mitochondria are key regulators of cell fate through controlling ATP generation and
releasing pro-apoptotic factors. Cardiac ischemia/reperfusion (I/R) injury to the coronary …

Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor
symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated …

Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …

Propionic acid (PPA) is used to study the role of mitochondrial dysfunction in
neurodevelopmental conditions like autism spectrum disorders. PPA is known to disrupt …

Reactive oxygen species (ROS) are by-products of aerobic metabolism and can also act as
signaling molecules to participate in multiple regulation of biological and physiological …