An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment

E Verdugo, I Puerto, MÁ Medina - Cancer Communications, 2022 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most aggressive and common malignant primary brain
tumor. Patients with GBM often have poor prognoses, with a median survival of∼ 15 months …

[HTML][HTML] Artificial intelligence in brain tumour surgery—an emerging paradigm

S Williams, H Layard Horsfall, JP Funnell… - Cancers, 2021 - mdpi.com
Simple Summary Artificial intelligence (AI) is the branch of computer science that enables
machines to learn, reason, and problem solve. In recent decades, AI has been developed …

[HTML][HTML] Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy

K White, K Connor, M Meylan, A Bougoüin… - Annals of …, 2023 - Elsevier
Background New precision medicine therapies are urgently required for glioblastoma
(GBM). However, to date, efforts to subtype patients based on molecular profiles have failed …

CXCR4-targeted nitric oxide nanoparticles deliver PD-L1 siRNA for immunotherapy against glioblastoma

HT Hsieh, HC Huang, CW Chung, CC Chiang… - Journal of Controlled …, 2022 - Elsevier
While immunotherapy has emerged as a promising strategy to treat glioblastoma multiforme
(GBM), the limited availability of immunotherapeutic agents in tumors due to the presence of …

Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

S Nag, B Bhattacharya, S Dutta, D Mandal… - ACS Biomaterials …, 2023 - ACS Publications
Glioblastoma (GBM) is an aggressive type of cancer that has led to the death of a large
population. The traditional approach fails to develop a solution for GBM's suffering life …

Profiling of circulating glial cells for accurate blood‐based diagnosis of glial malignancies

K O'Neill, N Syed, T Crook, S Dubey… - … Journal of Cancer, 2024 - Wiley Online Library
Here, we describe a blood test for the detection of glial malignancies (GLI‐M) based on the
identification of circulating glial cells (CGCs). The test is highly specific for GLI‐M and can …

[HTML][HTML] Lactoferrin and nanotechnology: the potential for Cancer treatment

TH Tran, PTT Tran, DH Truong - Pharmaceutics, 2023 - mdpi.com
Lactoferrin (Lf)—a glycoprotein of the transferrin family—has been investigated as a
promising molecule with diverse applications, including infection inhibition, anti …

[HTML][HTML] BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas

V Moreno, M Vieito, JM Sepulveda, V Galvao… - Nature …, 2023 - nature.com
Bromodomain and extraterminal proteins (BET) play key roles in regulation of gene
expression, and may play a role in cancer-cell proliferation, survival, and oncogenic …

[HTML][HTML] Mechanisms of long non-coding RNAs in biological characteristics and aerobic glycolysis of glioma

N Zhao, J Zhang, Q Zhao, C Chen, H Wang - International Journal of …, 2021 - mdpi.com
Glioma is the most common and aggressive tumor of the central nervous system. The
uncontrolled proliferation, cellular heterogeneity, and diffusive capacity of glioma cells …

Sexual-biased necroinflammation is revealed as a predictor of bevacizumab benefit in Glioblastoma

S Hiller-Vallina, L Mondejar-Ruescas… - Neuro …, 2024 - academic.oup.com
Background Glioblastoma (GBM) is a highly malignant brain tumor that affects men more
often than women. In addition, the former shows a poorer survival prognosis. To date, the …