Synthesis and anticancer activity of new hydrazide-hydrazones and their Pd (II) complexes

B Kocyigit-Kaymakcioglu, SS Yazici… - Letters in Drug …, 2019 - ingentaconnect.com
Background: Hydrazones, one of the important classes of organic molecules, are
pharmaceutical agents comprising–CO-NH-N= CH-group in the structure therefore and …

Straightforward synthesis of quinoxaline-furan bis-heterocyclic structures via a multicomponent reaction

H Farhid, HM Araghi, A Shaabani, B Notash - Journal of Molecular …, 2023 - Elsevier
An efficient and straightforward synthetic strategy based on the higher-order multicomponent
reactions (MCRs) is established for the synthesis of quinoxaline-furan bis-heterocyclic …

Synthesis and bioactivity of 1, 3-thiazolidine-2-thione derivatives against type III secretion system of Xanthomonas oryzae

H Tao, H Tian, S Jiang, X Xiang, W Ahmed… - Bioorganic & Medicinal …, 2019 - Elsevier
Targeting virulence factors of bacterial without affecting their growth and survival, has been
an initiative strategy for the development of novel anti-microbial agents. The type III secretion …

NHC catalysed direct addition of HMF to diazo compounds: synthesis of acyl hydrazones with antitumor activity

JPM António, RFM Frade, FMF Santos, JAS Coelho… - Rsc Advances, 2014 - pubs.rsc.org
NHC umpolung catalysis between 5-hydroxymethyl furfural (HMF) derivatives and diazo
compounds overcomes the usual multistep synthesis of acylhydrazones and gives direct …

In vitro and in vivo antiproliferative activity on lung cancer of two acylhydrazone based zinc (II) complexes

Q Chang, Y Xie, X Lu, Z Zong, E Zhang, S Cao… - Bioorganic …, 2024 - Elsevier
Two acylhydrazone based zinc (II) complexes [Zn (HL) 2 Cl 2 (CH 3 OH) 2](Zn1) and [ZnL
(AC)] 2 (Zn2) were synthesized from 3-(1-(salicyloylhydrazono) ethyl) pyridine (HL). Single …

Molecular design and synthesis of novel salicyl glycoconjugates as elicitors against plant diseases

Z Cui, J Ito, H Dohi, Y Amemiya, Y Nishida - PLoS One, 2014 - journals.plos.org
A new series of salicyl glycoconjugates containing hydrazide and hydrazone moieties were
designed and synthesized. The bioassay indicated that the novel compounds had no in vitro …

[HTML][HTML] An integrated approach to predict activators of NRF2-the transcription factor for oxidative stress response

Y Chushak, RA Clewell - Artificial Intelligence in the Life Sciences, 2024 - Elsevier
A variety of environmental and physiological conditions can cause oxidative stress that
damage cellular components such as DNA, proteins and lipids. Oxidative stress is …

Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones

Y Wang, H Yan, C Ma, D Lu - Bioorganic & Medicinal Chemistry Letters, 2015 - Elsevier
A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through
a useful procedure starting from amino alcohol and pyrimido dichloride. All the products …

Synthesis and bioactivity of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan

Z Cui, X Li, Y Nishida - Letters in Drug Design & Discovery, 2014 - ingentaconnect.com
A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were
synthesized. The antitumor tests showed that the title compounds exhibited promising …

含1, 2, 4-三唑酰腙类化合物的合成, 结构表征及生物活性

韩杰, 周晓霞, 陈思宝, 安悦 - 有机化学, 2014 - sioc-journal.cn
摘要以取代羧酸为起始原料, 经多步反应, 设计合成12 个中间体及16 个2-(3-取代-4-氨基-1, 2, 4-
三唑-5-硫基) 乙酰腙类化合物, 中间体2a~ 2d, 3a~ 3d 及目标产物4a~ 4p 均为新化合物. 借助IR …