Cystic fibrosis (CF) is the most common inherited disorder of childhood. The diagnosis of CF
has traditionally been based on clinical features with confirmatory evidence by sweat …

Improvements in outcomes for patients who have cystic fibrosis (CF) have been striking in
the last 30 years. Median survival now approaches the fifth decade of life. Advances in the …

Introduction von Recklinghausen neurofibromatosis (VRNF) is one of the most frequent and
clinically important Mendelian disorders in man, with an incidence of 1 in 3000 (Crowe et al …

Pancreatic fluid and electrolyte secretion was assessed in 56 patients with cystic fibrosis
(CF) and 56 non-CF control subjects undergoing pancreatic function testing while stimulated …

Cystic fibrosis (CF) is a fatal genetic disease with an especially high incidence in Caucasian
populations, where it has a frequency of approximately one in 2500 live births (11). There is …

Statistical analysis methods for gene mapping originated in counting recombinant and non-
recombinant offspring, but have now progressed to sophisticated approaches for the …

Five of the most variable loci detected in human DNA by hybridization with DNA fingerprint
probes have been cloned and characterized. Each locus consists of a tandem‐repetitive …

The exact aetiology of Crohn's disease is unknown, though it is clear from early
epidemiological studies that a combination of genetic and environmental risk factors …

The enormous complexity of biological systems at the molecular level must be answered
with powerful computational methods. Computational biology is a young field, but has seen …

Median cystic fibrosis (CF) survival has increased dramatically over time due to several
factors, including greater availability and use of antimicrobial therapies. During the …