Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

The progression of cancer is not only about the tumor cell itself, but also about other
involved players including cancer cell recruited immune cells, their released pro …

Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in
macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD …

Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …

Neutrophil granule serine proteases contribute to immune responses through cleavage of
microbial toxins and structural proteins. They induce tissue damage and modulate …

It has been known for many years that neutrophils and platelets participate in the
pathogenesis of severe sepsis, but the inter-relationship between these players is …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …