Several lines of evidence suggest a pathogenic role of insulin resistance on kidney
dysfunction. Potential mechanisms are mostly due to the effect of single abnormalities …

Adiponectin is secreted by the adipose tissue and is downregulated in states of obesity and
insulin resistance. There is a growing body of evidence indicating that adiponectin has …

Cytokine-induced inflammation is involved in the pathogenesis of type 2 diabetes mellitus
(DM). We investigated plasma concentrations and ex vivo production of cytokines and …

Background Adiponectin and leptin, two of the key cytokines secreted by adipocytes, have
been shown to be associated with cardiovascular disease. However, the association of …

Background The adipocytokines leptin and adiponectin have been variously associated with
diabetic microvascular complications. No comprehensive clinical data exist examining the …

Objective Adiponectin is secreted specifically from adipocytes, and improves insulin
sensitivity. Of its isoforms, the high molecular weight (HMW) complex is thought to be the …

Diabetic complication is comprised of a wide variety of pathophysiological factors involving
proinflammatory cytokines, adipokines, and oxidative stress, among others. Each of these …

Diabetes is an important health problem since the incidence of diabetes is continuously
increasing. Early diagnosis is important as type 2 diabetes begins long before we diagnose …

Adiponectin is the most abundant circulating adipokine, and it has insulin-sensitizing and
anti-inflammatory properties. Although it has been speculated that kidney function decline …

Although adiponectin, an adipocytokine released from adipose tissue, is thought to have anti-
atherogenic, anti-inflammatory, and insulin-sensitizing effects, it appears that high, rather …