Pathogenesis of cancers derived from thyroid follicular cells
The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …
Heterogeneity of thyroid cancer
E Chmielik, D Rusinek, M Oczko-Wojciechowska… - Pathobiology, 2018 - karger.com
There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …
[HTML][HTML] Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
I Landa, T Ibrahimpasic, L Boucai… - The Journal of …, 2016 - Am Soc Clin Investig
BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
[HTML][HTML] Integrated genomic characterization of papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
Dissecting anaplastic thyroid carcinoma: a comprehensive clinical, histologic, immunophenotypic, and molecular study of 360 cases
Background: Anaplastic thyroid carcinoma (ATC) is nearly always fatal. Large studies on
ATC are exceedingly rare. We aimed to study the clinical, genotypic, and histologic …
ATC are exceedingly rare. We aimed to study the clinical, genotypic, and histologic …
Complete Surgical Resection Following Neoadjuvant Dabrafenib Plus Trametinib in BRAFV600E-Mutated Anaplastic Thyroid Carcinoma
JR Wang, ME Zafereo, R Dadu, R Ferrarotto… - Thyroid, 2019 - liebertpub.com
Background: When achieved, complete surgical resection improves outcomes in anaplastic
thyroid carcinoma (ATC). However, most ATC patients present with advanced inoperable …
thyroid carcinoma (ATC). However, most ATC patients present with advanced inoperable …
[HTML][HTML] Molecular diagnosis and targeted treatment of advanced follicular cell-derived thyroid cancer in the precision medicine era
J Capdevila, A Awada, D Führer-Sakel… - Cancer Treatment …, 2022 - Elsevier
Most malignant thyroid tumours are initially treated with surgery or a combination of surgery
and radioactive iodine (RAI) therapy. However, in patients with metastatic disease, many …
and radioactive iodine (RAI) therapy. However, in patients with metastatic disease, many …
BRAF V600E mutation-specific antibody: a review
LL Ritterhouse, JA Barletta - Seminars in diagnostic pathology, 2015 - Elsevier
The significance of BRAF mutations in neoplasia was first recognized in 2002 when
mutations were discovered in a broad range of cancers. Numerous subsequent studies …
mutations were discovered in a broad range of cancers. Numerous subsequent studies …
Advances in thyroid pathology: high grade follicular cell-derived thyroid carcinoma and anaplastic thyroid carcinoma
B Xu, RA Ghossein - Advances in Anatomic Pathology, 2023 - journals.lww.com
Abstract In the upcoming World Health Organization fifth edition classification of endocrine
tumors, there were several major changes related to high grade follicular-derived thyroid …
tumors, there were several major changes related to high grade follicular-derived thyroid …
Immunohistochemical biomarkers in thyroid pathology
The application of immunohistochemistry to the diagnosis of thyroid lesions has increased
as new biomarkers have emerged. In this review, we discuss the biomarkers that are critical …
as new biomarkers have emerged. In this review, we discuss the biomarkers that are critical …