Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Endometrial function in women with polycystic ovary syndrome: a comprehensive review

S Palomba, TT Piltonen… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Polycystic ovary syndrome (PCOS) is the most common cause of
anovulatory infertility. An endometrial component has been suggested to contribute to …

Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls

SF Witchel, SE Oberfield, AS Peña - Journal of the Endocrine …, 2019 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

[HTML][HTML] The crucial role and mechanism of insulin resistance in metabolic disease

X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

X Qi, C Yun, L Sun, J Xia, Q Wu, Y Wang, L Wang… - Nature medicine, 2019 - nature.com
Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovulatory
dysfunction and polycystic ovaries, and is often accompanied by insulin resistance. The …

Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective

S Kumariya, V Ubba, RK Jha, JR Gayen - Autophagy, 2021 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a unification of endocrine and metabolic disorders and
has become immensely prevalent among women of fertile age. The prime organ affected in …

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

[HTML][HTML] Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

F He, Y Li - Journal of ovarian research, 2020 - Springer
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder.
Typically, it is characterized by hirsutism, hyperandrogenism, ovulatory dysfunction …

Polycystic ovary syndrome

R Azziz, E Carmina, ZJ Chen, A Dunaif… - Nature reviews Disease …, 2016 - nature.com
Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide.
The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic …