Background Randomized controlled trials almost always have some individuals with missing
outcomes. Inadequate handling of these missing data in the analysis can cause substantial …

OBJECTIVE: To quantify the degree of disagreement between the two most popular
methods for dealing with missing data: intention to treat (ITT) and per protocol (PP). STUDY …

The feasibility and efficacy of virtual reality job interview training (VR-JIT) was assessed in a
single-blinded randomized controlled trial. Adults with autism spectrum disorder were …

Purpose To compare the effects of cannabis extract (CE), delta-9-tetrahydrocannabinol
(THC), and placebo (PL) on appetite and quality of life (QOL) in patients with cancer-related …

Background: In recent years, armed conflicts in the Middle East have resulted in high rates of
exposure to traumatic events. Despite the increasing demand of mental health care …

BACKGROUND Snoring is extremely common in the general population and may indicate
OSA. However, snoring is not objectively measured during polysomnography, and no …

Background Clinical registries, which capture information about the health and healthcare
use of patients with a health condition or treatment, often contain patient-reported outcomes …

Cohen's kappa coefficient is commonly used for assessing agreement between
classifications of two raters on a nominal scale. Three variants of Cohen's kappa that can …

Objective To compare the efficacy and safety of treatment with infliximab plus methotrexate
with methotrexate alone in methotrexate-naive patients with active psoriatic arthritis (PsA) …

This book provides practical guidance for statisticians, clinicians, and researchers involved
in clinical trials in the biopharmaceutical industry, medical and public health organisations …