Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and
activities of transcriptional factors involved in both cancer initiation and progression through …

Although the existence of cancer stem cells (CSCs) was first proposed over 40 years ago,
only in the past decade have these cells been identified in hematological malignancies, and …

Improving tumor immunogenicity is critical for increasing the responsiveness of triple-
negative breast cancer (TNBC) to anti-PD-(L) 1 treatment. Here, we verified that chidamide …

The sources and consequences of nongenetic variability in metastatic progression are
largely unknown. To address these questions, we characterized a transcriptional regulatory …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

Urinary bladder cancer is a common malignancy, being characterized by substantial patient
mortality and management cost. Its high somatic-mutation frequency and molecular …

Targeted diagnosis and therapy enable precise tumor detection and treatment. Successful
examples for precise tumor targeting are diagnostic and therapeutic radioligands. However …

Mesothelioma is an aggressive cancer that is associated with exposure to asbestos.
Although asbestos is banned in several countries, including the UK, an epidemic of …