Basic biology of Trypanosoma cruzi
AA Zuma, E dos Santos Barrias… - Current pharmaceutical …, 2021 - ingentaconnect.com
The present review addresses basic aspects of the biology of the pathogenic protozoa
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …
SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition
JE Hanson, H La, E Plise, YH Chen, X Ding… - PLoS …, 2013 - journals.plos.org
Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs)
used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for …
used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for …
Cancer stem cells and hepatocellular carcinoma
Z Yao, L Mishra - Cancer biology & therapy, 2009 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with a median
survival of 6 to 16 months. Factors responsible for the poor prognosis include late onset …
survival of 6 to 16 months. Factors responsible for the poor prognosis include late onset …
Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in …
T Singh, R Prasad, SK Katiyar - Epigenetics, 2013 - Taylor & Francis
Non-small-cell lung cancer (NSCLC) represents approximately 80% of all types of lung
cancer. Here, we report the chemotherapeutic effect of honokiol, a phytochemical from …
cancer. Here, we report the chemotherapeutic effect of honokiol, a phytochemical from …
Histone deacetylase (HDAC) inhibitory and antiproliferative activities of phenolic-rich extracts derived from the rhizome of Hydnophytum formicarum Jack.: sinapinic …
T Senawong, S Misuna, S Khaopha… - … and Alternative Medicine, 2013 - Springer
Abstract Background The rhizome of Hydnophytum formicarum Jack., a medicinal plant
known in Thai as Hua-Roi-Roo, has been used in Thai traditional herbal medicine for …
known in Thai as Hua-Roi-Roo, has been used in Thai traditional herbal medicine for …
Reversal of Resistance in Targeted Therapy of Metastatic Melanoma: Lessons Learned from Vemurafenib (BRAFV600E-Specific Inhibitor)
AX Torres-Collado, J Knott, AR Jazirehi - Cancers, 2018 - mdpi.com
Malignant melanoma is the most aggressive form of skin cancer and has a very low survival
rate. Over 50% of melanomas harbor various BRAF mutations with the most common being …
rate. Over 50% of melanomas harbor various BRAF mutations with the most common being …
AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit
TY Lin, J Fenger, S Murahari, MD Bear… - Blood, The Journal …, 2010 - ashpublications.org
Histone hypoacetylation occurs in many cancers and inhibition of histone deacetylation is a
promising approach to modulate these epigenetic changes. Our laboratory previously …
promising approach to modulate these epigenetic changes. Our laboratory previously …
A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells
L Liu, B Chen, S Qin, S Li, X He, S Qiu, W Zhao… - Biochemical and …, 2010 - Elsevier
Many studies have demonstrated that histone deacetylase (HDAC) inhibitors induce various
tumor cells to undergo apoptosis, and such inhibitors have been used in different clinical …
tumor cells to undergo apoptosis, and such inhibitors have been used in different clinical …
Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells
L Wasim, M Chopra - Cellular Oncology, 2018 - Springer
Purpose Various combinations of drugs may be effective in the treatment of different types of
cancer. Previously, we have shown that combinations of the histone deacetylase inhibitor …
cancer. Previously, we have shown that combinations of the histone deacetylase inhibitor …
A structural insight into hydroxamic acid based histone deacetylase inhibitors for the presence of anticancer activity
Histone deacetylase inhibitors (HDACi) have been actively explored as anti-cancer agents
due to their ability to prevent deacetylation of histones, resulting in uncoiling of chromatin …
due to their ability to prevent deacetylation of histones, resulting in uncoiling of chromatin …