Endosymbiosis in trypanosomatids: the bacterium division depends on microtubule dynamism
JR Moraes, A Barrinha, LSG de Lima, JC Vidal… - Experimental Cell …, 2024 - Elsevier
Microtubules are components of the cytoskeleton that perform essential functions in
eukaryotes, such as those related to shape change, motility and cell division. In this context …
eukaryotes, such as those related to shape change, motility and cell division. In this context …
5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines
N Al-Rayyan, LM Litchfield, MM Ivanova, BN Radde… - Cancer letters, 2014 - Elsevier
COUP-TFII is reduced in endocrine-resistant breast cancer cells and is negatively
associated with tumor grade. Transient re-expression of COUP-TFII restores antiestrogen …
associated with tumor grade. Transient re-expression of COUP-TFII restores antiestrogen …
Pyridine derivative of succinic acid hydroxylamide enhances the cytotoxic effect of cisplatin and actinomycin D
BA Tretyakov, NV Filatova, VA Mumyatova… - Bulletin of Experimental …, 2023 - Springer
We studied the possibility of inhibition of histone deacetylases (HDAC) in the nuclear extract
of HeLa cells by N1-hydroxy-N4-(pyridin-4-yl) succinamide (compound 1). Compound 1 …
of HeLa cells by N1-hydroxy-N4-(pyridin-4-yl) succinamide (compound 1). Compound 1 …
Determination of chidamide in rat plasma by LC‐MS and its application to pharmacokinetics study
X Wang, M Chen, C Wen, Q Zhang… - Biomedical …, 2013 - Wiley Online Library
ABSTRACT A sensitive and selective liquid chromatography mass spectrometry method for
determination of chidamide in rat plasma was developed. After addition of linezolid as …
determination of chidamide in rat plasma was developed. After addition of linezolid as …
Chaetocin—A histone methyltransferase inhibitor—Impairs proliferation, arrests cell cycle and induces nucleolar disassembly in Trypanosoma cruzi
AA Zuma, J de Oliveira Santos, I Mendes, W de Souza… - Acta tropica, 2017 - Elsevier
The Trypanosomatidae family includes pathogenic species of medical and veterinary
interest. Chagas disease is endemic in Latin America, and about 8 million people are …
interest. Chagas disease is endemic in Latin America, and about 8 million people are …
Synthesis, characterization, and evaluation of Cd[L-proline]2, a novel histone deacetylase inhibitor that induces epigenetic modification of histone deacetylase …
A Chidambaram, A Sekar, K SH… - Investigational New …, 2017 - Springer
Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene
expression through their effects on the compact chromatin structure. In clinical studies …
expression through their effects on the compact chromatin structure. In clinical studies …
Histone deacetylase inhibitor potentiates chemotherapy-induced apoptosis through Bim upregulation in Burkitt's lymphoma cells
AC dos Santos Ferreira, RA Fernandes… - Journal of cancer …, 2012 - Springer
Purpose Although polychemotherapy regiments have improved clinical outcome for Burkitt's
lymphoma (BL) patients, salvage treatment of patients with refractory disease remains very …
lymphoma (BL) patients, salvage treatment of patients with refractory disease remains very …
[PDF][PDF] Hydroxamic acid based histone deacetylase inhibitors: Present and future prospectives as anticancer agent
Histone deacetylases are set of enzymes that have been of interest in drug discovery for the
last more than 3 decades. They are responsible for cleaving of acetyl groups from acetyl …
last more than 3 decades. They are responsible for cleaving of acetyl groups from acetyl …
The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells
JI Weberpals, AM O'Brien, N Niknejad… - Cancer cell …, 2011 - Springer
Abstract Background The inhibition of Br east Ca ncer 1 (BRCA1) expression sensitizes
breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically …
breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically …