Children suffering from drug-resistant epilepsy must be quickly referred to a comprehensive
pediatric epilepsy center for a thorough presurgical evaluation. Early referral allows for early …

Background Early-onset epileptic encephalopathy (EOEE) is a severe convulsive disorder
with a poor developmental prognosis. Although it has been associated with mutations in a …

Background Early-onset developmental and epileptic encephalopathy (DEE) is
characterized by repeated seizures beginning within 3 months of birth and severe interictal …

High‐throughput sequencing (HTS) improved the molecular diagnosis in individuals with
intellectual deficiency (ID) and helped to broaden the phenotype of previously known …

Interventions: We adjusted the antiepileptic strategy to oral levetiracetam and topiramate,
and intravenous administration of adrenocorticotropic hormone (ACTH) for 2 weeks …

Aims To investigate clinical characteristics and surgery outcomes of young children with
focal cortical dysplasia (FCD) type II. Methods Young children (onset age≤ 6 years) with …

Recent advances in genetics have determined that a number of epilepsy syndromes that
occur in the first year of life are associated with genetic etiologies. These syndromes range …

Objectives: Identify the etiology of neonatal seizures. Review the appropriate evaluation of
neonatal seizures. Outline the management options available for neonatal seizures. Identify …

Background We evaluated changes in genetic testing for neonatal-onset epilepsy and
associated short-term outcomes over an 8-year period among a cohort of patients in the …

Objectives Genetics of epilepsy are highly heterogeneous and complex. Lesions detected
involve genes encoding various types of channels, transcription factors, and other proteins …