Although targeting the tumor metabolism is performed in cooperation with immunotherapy in
the era of precision oncology, ignorance of immune cells' metabolism has resulted in …

Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for
maintaining immunological balance and are a significant component of the …

Prioritizing treatments for individual patients with cancer remains challenging, and
performing coclinical studies using patient-derived models in real time is often unfeasible …

Regulatory T cells (Tregs) are critical immunosuppressive cells that are frequently present in
the tumor microenvironment of solid cancers and enable progression of tumors toward …

Carbon ion beams have the unique property of higher linear energy transfer, which causes
clustered damage of DNA, impacting the cell repair system. This sometimes triggers …

The immune system plays a crucial role in recognizing and eliminating pathogenic
substances and malignant cells in the body. For cancer treatment, immunotherapy is …

Clear cell renal cell carcinoma (ccRCC) is an aggressive malignant tumor. Disulfidptosis is a
new programmed cell death mechanism, which is characterized by the abnormal …

Primary or secondary (ie, acquired) resistance is a common occurrence in cancer patients
and is often associated with high numbers of T regulatory (T reg) cells (CD4+ CD25+ …

Purpose: To assess the impact of neoadjuvant chemotherapy (NACT) on the tumor immune
microenvironment (TIME) in gynaecological tumors, with a focus on understanding the …

The therapeutic modes of cancers have been profoundly renovated by immunotherapies,
which have shown extraordinary treating efficacy in certain tumor entities. However, the …