Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

NLRP3 inflammasome is a vital player in macrophages pyroptosis, which is a type of
proinflammatory cell-death and takes part in the pathogenesis of atherosclerosis. In this …

Inflammasomes are intracellular complexes involved in the innate immunity that convert
proIL‐1β and proIL‐18 to mature forms and initiate pyroptosis via cleaving procaspase‐1 …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …