Tissue homeostasis and inflammation

ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Nanoparticle toxicology

W Yang, L Wang, EM Mettenbrink… - Annual Review of …, 2021 - annualreviews.org
Nanoparticles from natural and anthropogenic sources are abundant in the environment,
thus human exposure to nanoparticles is inevitable. Due to this constant exposure, it is …

Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression

A Sattiraju, S Kang, B Giotti, Z Chen, VJ Marallano… - Immunity, 2023 - cell.com
Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …

Hypoxia-modified cancer cell metabolism

W Al Tameemi, TP Dale, RMK Al-Jumaily… - Frontiers in cell and …, 2019 - frontiersin.org
While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes

AA Tirpe, D Gulei, SM Ciortea, C Crivii… - International journal of …, 2019 - mdpi.com
Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

In situ forming injectable hydrogels for drug delivery and wound repair

R Dimatteo, NJ Darling, T Segura - Advanced drug delivery reviews, 2018 - Elsevier
Hydrogels have been utilized in regenerative applications for many decades because of
their biocompatibility and similarity in structure to the native extracellular matrix. Initially …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast

A De Pieri, Y Rochev, DI Zeugolis - NPJ Regenerative Medicine, 2021 - nature.com
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Metabolic reprogramming in clear cell renal cell carcinoma

HI Wettersten, OA Aboud, PN Lara Jr… - Nature Reviews …, 2017 - nature.com
Research in many cancers has uncovered changes in metabolic pathways that control
tumour energetics and biosynthesis, so-called metabolic reprogramming. Studies in clear …

Oxygen-Deficient Tungsten Oxide (WOx) Nanobelts with pH-Sensitive Degradation for Enhanced Sonodynamic Therapy of Cancer

Y Zhou, N Yang, F Gong, Y Wang, X Yang, Y Dai… - ACS …, 2022 - ACS Publications
The further bioapplications of sonodynamic therapy (SDT) were hindered by the inadequate
efficiency and poor degradability of sonosensitizers and the hypoxic tumor …