High development costs and low success rates in bringing new medicines to the market
demand more efficient and effective approaches. Identified by the FDA as a valuable …

Pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation can be used as an
'applied science'tool to provide answers on efficacy and safety of new drugs faster and at a …

It is widely recognized that pharmacokinetic optimization needs to be addressed early in
drug discovery to reduce the high failure rate in bringing drugs to market. Poor absorption …

Abstract Model-based drug development (MBDD) has been recognized as a concept to
improve the efficiency of drug development. The acceptance of MBDD from regulatory …

Four elements are crucial to successful pharmacokinetic-pharmacodynamic (PK/PD)
modelling and simulation for efficient and effective rational drug development:(i) mechanism …

Thorough characterization of the plasma pharmacokinetics (PK) is a critical step in clinical
development of novel therapeutics and is routinely performed for small molecules and …

Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on
nutraceuticals, the compounds derived from natural sources, which are usually multi …

High drug attrition rates remain a critical issue in oncology drug development. A series of
steps during drug development must be addressed to better understand the …

Neutropenia is a serious toxic complication of chemotherapeutic treatment. For years,
mathematical models have been developed to better predict hematological outcomes during …

Designed as a comprehensive text for students and professionals pursuing careers in the
fields of bioinformatics, molecular biology, pharmacy and drug research, the Fifth Edition …