The mixture of fatty acids available to FADS2 in any tissue defines the product mixture
available for further synthesis of membrane lipids and signaling molecules and may be …

Since it was first described> 20 yr ago, the SPOC domain (Spen paralog and ortholog C-
terminal domain) has been identified in many proteins all across eukaryotic species. SPOC …

Importance Immune checkpoint inhibitors (ICIs) have improved survival outcomes of patients
with advanced esophageal squamous cell carcinoma in both first-and second-line settings …

Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell
functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular …

Background: Shikonin, a small molecule inhibitor of pyruvate kinase 2 (PKM2), has been
demonstrated to play the antitumor effect in various cancers. However, the specific effects …

Background: Considering the role of immunity and ferroptosis in the invasion, proliferation
and treatment of cancer, it is of interest to construct a model of prognostic-related differential …

Background The patients with dual oesophageal squamous cell carcinoma (ESCC) and
hypopharyngeal cancer (HPC) have poor prognosis; their underlying genetic pathogenesis …

Basal progenitor cells serve as a stem cell pool to maintain the homeostasis of the
epithelium of the foregut, including the esophagus and the forestomach. Aberrant genetic …

Lung cancer is the leading cause of cancer‐related mortality in men and women globally.
Non‐small cell lung cancer (NSCLC) is the most prevalent subtype, accounting for 85–90 …

Background. Hepatocellular carcinoma (HCC), ranking as one of the most common
malignant tumors, is one of the leading causes of cancer death, with a poor prognosis …