Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …

Learning to associate certain contexts with threat and adapting to changing environmental
contingencies by learning that such contexts are no longer associated with threat are both …

Growing evidence from male rodent and human studies suggests that cannabidiol (CBD)
modulates the expression of aversive memories and anxiety-related responses. The limited …

Early life stress is associated with long-term and pervasive adverse effects on
neuroendocrine development, affecting normal cognitive and emotional development …

Cluster headache (CH) is characterized by recurrent episodes of excruciatingly painful,
unilateral headache attacks typically accompanied by trigeminal autonomic symptoms. Due …

The lateral habenula (LHb) is an epithalamic structure connected with both the basal
ganglia and the limbic system and that exerts a major influence on midbrain monoaminergic …

Peripheral nerve and spinal cord injuries, along with other painful syndromes such as
fibromyalgia, diabetic neuropathy, chemotherapeutic neuropathy, trigeminal neuralgia …

Gender is considered as a pivotal determinant of mental health. Indeed, several psychiatric
disorders such as anxiety and depression are more common and persistent in women than …

Increasing evidence points to the engagement of the lateral habenula (LHb) in the selection
of appropriate behavioral responses in aversive situations. However, very few data have …

Lateral habenula is believed to encode negative motivational stimuli and plays key roles in
the pathophysiology of psychiatric disorders. However, how habenula activities are …