The concept of synthetic lethality has been widely applied to identify therapeutic targets in
cancer, with varying degrees of success. The standard approach normally involves …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

Recent studies have shown that a strategy aiming for containment, not elimination, can
control tumour burden more effectively in vitro, in mouse models and in the clinic. These …

The interplay of positive and negative interactions between drug-sensitive and resistant cells
influences the effectiveness of treatment in heterogeneous cancer cell populations. Here, we …

Background Adaptive therapy aims to tackle cancer drug resistance by leveraging resource
competition between drug-sensitive and resistant cells. Here, we present a theoretical study …

Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical
research due to their exceptional attributes, including superior loading capacity …

Cancer is among the most common causes of death for dogs (and cats) and humans in the
developed world, even though it is uncommon in wildlife and other domestic animals. We …

Ganoderma has served as a valuable food supplement and medicinal ingredient with
outstanding active compounds that are essential for human protection against chronic …

The emergence of treatment-resistant clones is a critical barrier to cure in patients with
urothelial carcinoma. Setting the stage for the evolution of resistance, urothelial carcinoma is …

Rapid evolution is ubiquitous in nature. We briefly review some of this quite broadly,
particularly in the context of response to anthropogenic disturbances. Nowhere is this more …