▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …

The recent discovery of the mode of interaction between a group of microbial proteins known
as superantigens and the immune system has opened a wide area of investigation into the …

Superantigens activate T-cells by linking the T-cell receptor to MHC class II on antigen-
presenting cells, and novel reactivity can be introduced by fusing the superantigen to a …

The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent
activator of T lymphocytes when presented on major histocompatibility complex (MHC) class …

As a Gram-positive cocci existing in nature, Staphylococcus has a variety of species, such as
Staphylococcus aureus and Staphylococcus epidermidis, etc. Growing evidence reveals that …

Improvement of cancer therapy by introducing new concepts is still urgent even though there
have been major advancements lately. Immunotherapy is well on the way to becoming an …

PURPOSE To establish the maximum-tolerated dose (MTD) and define the toxicities of a
single-dose infusion of PNU-214565, a recombinant Escherichia coli-derived fusion protein …

Antibody-targeted superantigens have a potential to become useful drugs for tumor therapy.
However, clinical practice has identified several issues that need to be addressed to …

We have recently demonstrated that the superantigen staph‐ylococcal enterotoxin A (SEA)
conjugated to colon‐carcinoma‐reactive monoclonal antibodies (MAbs) directs T cells to …

Clearer evidence for immune surveillance in malignancy and the identification of many new
tumour-associated antigens (TAAs) have driven novel vaccine and antibody-targeted …