Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

The traditional serrated adenoma is the least common colorectal serrated polyp. The
clinicopathological features and molecular drivers of these polyps require further …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

Colorectal cancer (CRC) is a heterogeneous disorder than arises via multiple distinct
pathways, such as the serrated pathway, in which serrated polyps (including variants of …

The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …