Oxidative stress (OS), caused by the imbalance between the generation and detoxification of
reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

This article updates the Calcium Hypothesis of Alzheimer's disease and brain aging on the
basis of emerging evidence since 1994 (The present article, with the subtitle “New evidence …

Vascular endothelial growth factor A (VEGF-A) is a validated therapeutic target in several
angiogenic-and vascular permeability–related pathological conditions, including certain …

The CA1 (cornu ammonis) region of hippocampus is selectively vulnerable to a variety of
metabolic and cytotoxic insults, which is mirrored in a delayed neuronal death of CA1 …

A critical role in place learning has been attributed to place cells within the cornu ammonis 1
(CA1) sector of the hippocampus in rodents. The role of CA1 cells in the human …

Transient global ischemia selectively damages neurons in specific brain areas. A
reproducible pattern of selective vulnerability is observed in the dorsal hippocampus of …

Oxidative stress is a common etiological feature of neurological disorders, although the
pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration …

Abstract The Oxidative Stress Theory of Aging has had tremendous impact in research
involving aging and age-associated diseases including those that affect the nervous system …

An increasing body of evidence suggests that alterations in neurogenesis and oxidative
stress are associated with a wide variety of CNS diseases, including Alzheimer's disease …